Friday, October 4, 2013

Uniquely Female: Understanding Alpha-Lactalbumin In Health And Disease










Alpha-lactalbumin (ALA) is a protein.  A protein is made of amino acids.  Amino acids are like Legos – building blocks that are used to make proteins.  (Forgive me, I want to make this very simple, in consideration of those readers who barely made it through high school biology and hated every minute of it.  I love you and I want and need for you to understand this stuff.)
ALA is a protein that is uniquely female:  men don’t make it.  Ever.  And women only make ALA under one circumstance – when they are breastfeeding.
ALA begins to be made by the cells that line the ducts of the breast during the third trimester of pregnancy.  Sounds sensible, right?  This is the time when the breasts are ramping up for milk production.
If a women delivers a baby and then breastfeeds her infant, the cells that line the ducts of the breast continue to make ALA.  They will do so as long as she continues to breastfeed.
A woman who does not breastfeed her infant after she delivers her baby will no longer make ALA.  We say that ALA is “retired” because it is is no longer needed and is, therefore, no longer made.
Oh, BTW, what does ALA do?  What function does it serve?  ALA increases the amount of glucose entering the cells that line the ducts of the breast so that they have the EXTRA FUEL they need to make milk.  Also, ALA regulates the amount of water contained in breast milk.  This what ALA does and why it is only made by women who are either getting ready to, or actually are breastfeeding.
To summarize:  ALA is made only by women, and only if they are either getting ready to breastfeed (third trimester of pregnancy) or actually are breastfeeding.
Men don’t make ALA ever.  Sorry, guys; you just don’t need it and wouldn’t know what to do with if it we gave it to you.
This is the nature of the universe of ALA when all is proceeding according to plan.
But cancer is another whole universe, isn’t it?  (Shall we say, hell?  I think so.)
Breast cancer cells, which in approximately 85% of cases arise from the normal cells that line the ducts of the breast, also make ALA! You see, cancer cells are crazy.  They go wild – genetically and behaviorally – and they start spitting out all kinds of proteins, including ALA.
And, as I say, the majority of breast cancer cells – crazy lunatics that they are – also make ALA.
So, let’s say someone – oh, like, Professor Vincent Tuohy of the Cleveland Clinic – makes a vaccine against ALA and then primes the immune system by virtue of this vaccine so that whenever the immune system “sees” a cell that is “expressing” (i.e., making) ALA, it DESTROYS IT LIKE A HEAT-SEEKING MISSILE.  Any breast cancer cell – like the majority of tumor cells found in women with breast cancer – that makes ALA would be, metaphorically speaking, VAPORIZED.
Tuohy’s vaccine – the world’s first preventive breast cancer vaccine (sorry, Fran Visco of the impressive National Breast Cancer Coalition on Capitol Hill, he beat you and your, well, well-intentioned Artemis Project congregation to the punch by, oh, about 12 years) – does just that:  IT VAPORIZES ALL BREAST CANCER CELLS THAT EXPRESS ALA.  Tuohy’s vaccine targets ALA.  Any cell expressing ALA is annihilated by the Seal Team Six immune system primed by Tuohy’s vaccine.
Get it?  Simple.  Divine.  Like truth, beauty, love, and joy, Tuohy’s vaccine works every time.
Tuohy’s vaccine is 100% effective in preventing breast cancer in three animal models.
Tuohy’s vaccine is completely safe.
Tuohy’s vaccine was thoroughly vetted by a panel of scientific experts on the editorial advisory board of Nature Medicine before the paper that announced his discovery and reported the results of his experiments was published in May 2010.  So, ladies, this is no joke/hoax/too-good-to-be-true baloney.  It’s a proven thing.
Tuohy’s vaccine is ready for clinical testing in women to see if it is safe (i.e., a Phase I study).
That’s what you need to know about alpha-lactalbumin and Tuohy’s vaccine.
Well, actually, there’s more you need to know, more we all need to know:  When will Tuohy’s vaccine receive the funding it needs (~6 million) to begin the Phase I study to see if it’s safe for use in women?  I mean, come on, people.  When?
God knows.  And I, for one, trust in God to make that answer clear to us very soon.  So, stay tuned.

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